Dr Satyam Kumar Agrawal
Professor (Research)

satyam.ka@chitkara.edu.in

Expert Areas : Biotechnology, Mammalian Cell Culture, Anticancer Biology, Nanotechnology, Molecular Biology, Imaging

Dr. Satyam Kumar Agrawal is a biotechnologist with more than 17 years experience in Mammalian Cell Culture, designing and performing experiments with a focus on Cell based assays to identify mechanism of action of various plant isolates and synthetic molecules, anticancer drug delivery, apoptosis, transfection and Cell Line development. He is well versed with latest Molecular Biology, Nanotechnology, Genomics, Flow cytometry and Microscopic techniques.

Dr. Satyam Kumar Agrawal completed his Masters in Biotechnology from University of Allahabad and earned his PhD from Guru Nanak Dev University, while working as CSIR fellow from Indian Institute of Integrative Medicine, Jammu. Later, he worked as Research Associate at CDRI, Lucknow as Post-Doc and as Scientist-II at NIPER, Mohali. He also has industrial experience as Principal Scientific Officer – Oncology, at a Private Biotech company. He further joined Panjab University as Scientific Assistant and later as Project Scientist at IGIB, Delhi and then as Scientist-C at Div. of RBMCH, at ICMR, New Delhi, in project based positions. Until most recently he worked as Professor at School of Pharmacy, Baddi University, HP.

Currently, he is working as Professor (Research) at Chitkara University Research and Innovation Network (CURIN), Chitkara University, Rajpura, Punjab.

His current focus areas are in vitro cell biology, mechanistic profiling of lead compounds with emphasis on nutraceuticals and development of target specific nanotherapeutics from natural products alone and in combinatorial mode against cancer. His research interests are also in studying in vitro stress (Hypoxia, Heat, Cold & UV) and the anti-cancer & anti-oxidant potential of new molecules.

  • Research
  • Teaching
  • Consulting
  • Awards
  • Patents
  • Education
  • Service

Publications

  1. Satyam Kumar Agrawal, Madhunika Agrawal, PR Sharma, Khursheed Ahmad, AS Shawl, Saroj Arora, AK Saxena. Anagallis arvensis induces apoptosis in HL-60 cells through ROS-mediated mitochondrial pathway. Nutrition and Cancer: An International Journal, 73(11-12), 2021, 2720-2731. https://doi.org/10.1080/01635581.2020.1856893.
  2. Sumita Chakraborty; Sunanda Singhmar; Dayanidhi Singh; Mahua Maulik; Rutuja Patil; Satyam Kumar Agrawal; Anushree Mishra; Madeeha Ghazi; Archana Vats; Vivek T Natarajan; Sanjay Juvekar; Bhavana Prasher, Mitali Mukerji. Lymphoblastoid Cell Lines from healthy individuals of extreme constitution types display differences in cell proliferation rates and response to UV. Cell Cycle, 20(9), 2021, 903-913. https://doi.org/10.1080/15384101.2021.1909884.
  3. M Agrawal, SK Yadav, Satyam Kumar Agrawal and S Karmakar. Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line. Journal of Nanoparticle Research, 19, 2017, 272, 1-9.
  4. Bhavana Prasher, Binuja Varma, Arvind Kumar, Bharat Krushna Khuntia, Rajesh Pandey, Ankita Narang, Pradeep Tiwari, Rintu Kutum, Debleena Guin, Ritushree Kukreti, Debasis Dash, Trisutra Ayurgenomics Consortium (SK Agrawal), Mitali Mukerji. Ayurgenomics for stratified medicine: TRISUTRA consortium initiative across ethnically and geographically diverse Indian populations. Journal of Ethnopharmacology, 197, 2017, 274-293.
  5. R Sonawane, H Harde, M Katariya, Satyam Kumar Agrawal and S Jain. Solid Lipid Nanoparticles Loaded Topical Gel Containing Combination Drugs: An Approach to Offset Psoriasis. Expert Opinion on Drug Delivery, 11(12), 2014, 1833-1847.
  6. Satyam Kumar Agrawal, M Agrawal, PR Sharma, BD Gupta, S Arora and AK Saxena. Induction of Apoptosis in Human promyelocytic Leukemia HL60 cells by an Extract from Erythrina suberosa Stem Bark. Nutrition and Cancer: An International Journal, 63(5), 2011, 802–813.
  7. S Kulthe, N Inamdar, C Godhani, Y Choudhari, S Shirolikar, L Borde, K Thanki, M Agrawal, Satyam Kumar Agrawal, S Jain and V Mourya. Mixed Micellar Nanocarriers for Controlled and Targeted Delivery of Paclitaxel.   Journal of Nanopharmaceutics and Drug Delivery, 2(1), 2014, 69-79.
  8. Devinder Kaur, DS Sogi, Satyam Kumar Agrawal. In-vitro anti-proliferative activities of Lycopene against prostrate, lung, colon and breast cancer cell lines. International Journal of Food and Nutritional Sciences, 3(4), 2014, 91-97.
  9. RP Chauhan, R Mathur, G Singh, N Bag, S Singh, K Chuttani, BSH Kumar, Satyam Kumar Agrawal and AK Mishra. Evaluation of biotinylated magnetic nanoparticles for tumour imaging. Journal of Material Science, 48, 2013, 3913–3925.
  10. BS Arora, E Sharma, Satyam Kumar Agrawal and M Agrawal. In vitro Cytotoxicity of Methanol Extract from Aerial Parts of Aralia cachemirica and Purified Continentalic Acid. Indian Journal of Pharmaceutical Sciences, 77(6), 2015, 792-795.
  11. SM Sondhi, J Singh, Satyam Kumar Agrawal, AK Saxena and P Roy. Synthesis of pyrimidine and condensed pyrimidine derivatives and their evaluation for anti-inflammatory activity. Med Chem Res. 21, 2012, 91–99.
  12. TS Thind, G Rampal, Satyam Kumar Agrawal, AK Saxena and S Arora. Evaluation of cytotoxic and radical-scavenging activities of root extracts of Schleichera oleosa (Lour.) Oken. Natural Product Research, 26(18), 2012, 1728–1731.
  13. SM Sondhi, J Singh, P Roy, Satyam K Agrawaland AK Saxena. Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation. Med Chem Res. 20, 2011, 887–897.
  14. AK Tripathi, D Mukherjee, S Koul, SC Taneja, Satyam Kumar Agrawal, PR Sharma and AK Saxena. Synthesis and cytotoxicity of novel benzopyran derivatives. Indian Journal of Chemistry, 50B, 2011, 1619-1629.
  15. SM Sondhi, R Rani, P Roy, Satyam Kumar Agrawal and AK Saxena. Synthesis, Anti-Inflammatory, and Anticancer Activity Evaluation of Some Heterocyclic Amidine and Bis-Amidine Derivatives. J Heterocyclic Chemistry, 48, 2011, 921-926.
  16. A Kamal, BA Kumar, P Suresh, Satyam Kumar Agrawal, G Chashoo, SK Singh and AK Saxena. Synthesis of 4b-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities. Bioorganic & Medicinal Chemistry, 18, 2010, 8493–8500.
  17. S Gupta, K Kalani, M Saxena, SK Srivastava, Satyam Kumar Agrawal, N Suri and AK Saxena. Cytotoxic Evaluation of Semisynthetic Ester and Amide Derivatives of Oleanolic Acid. Natural Product Communications, 5(10), 2010, 1567 – 1570.
  18. V Dhuna, K Dhuna, J Singh, AK Saxena, Satyam Kumar Agrawal and SS Kamboj. Isolation, purification and characterization of an N-acetyl-D-lactosamine binding mitogenic and anti-proliferative lectin from tubers of a cobra lily Arisaema utile. Advances in Bioscience and Biotechnology, 1, 2010, 79-90.
  19. V Dhuna, K Dhuna, J Singh, AK Saxena, Satyam Kumar Agrawal and SS Kamboj. Purification and characterization of an Anti-proliferative and mitogenic plant lectin from tubers of Arisaema speciosum. Pharmacogonosy Journal, 2(9), 2010, 272-283.
  20. VM Gohil, Satyam Kumar Agrawal, AK Saxena, D Garg, C Gopimohan and KK Bhutani. Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity. Indian Journal of Experimental Biology, 48, 2010, 265-268.
  21. SM Sondhi, R Rani, J Singh, P Roy, Satyam Kumar Agrawal and AK Saxena. Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. Bioorganic & Medicinal Chemistry Letters 20, 2010, 2306–2310.
  22. TS Thind, G Rampal, Satyam Kumar Agrawal, AK Saxena and Saroj Arora. Diminution of free radical induced DNA damage by extracts/fractions from bark of Schleichera oleosa (Lour.) Oken. Drug and Chemical Toxicology, 33(4), 2010, 329-336.
  23. SM Sondhi, J Singh, PP Gupta, Satyam Kumar Agrawal and AK Saxena. Conventional and microwave assisted synthesis of small molecule based biologically active hetrocyclic amidine derivatives. European Journal of Medicinal Chemistry, 45, 2010, 902–908.
  24. SM Sondhi, J Singh, R Rani, PP Gupta, Satyam Kumar Agrawal and AK Saxena. Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. European Journal of Medicinal Chemistry, 45, 2010, 555–563.
  25. M Sharma, Satyam Kumar Agrawal, PR Sharma, BS Chadha, MK Khosla and AK Saxena. Cytotoxic and apoptotic activity of essential oil from Ocimum viride towards COLO 205 cells. Food and Chemical Toxicology, 48, 2010, 336–344.
  26. SM Sondhi, R Rani, PP Gupta, Satyam Kumar Agrawal and AK Saxena. Synthesis, anticancer and anti-inflammatory activity evaluation of some novel methanesulfonamide and amidine derivatives of 3, 4-diaryl-2-imino-4-thiazolines. Molecular Diversity, 13, 2009, 357-366.
  27. Satyam Kumar Agrawal, M Sharma, PR Sharma, S Arora and AK Saxena. Stem bark extract of Erythrina suberosa induce apoptosis in human cancer cells (Abstract). Annals of Oncology, 20(S3), 2009, iii36-iii37; D04.
  28. SM Sondhi, R Rani, P Roy, Satyam Kumar Agrawal and AK Saxena. Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Bioorganic & Medicinal Chemistry Letters, 19, 2009, 1534–1538.
  29. PB Reddy, Satyam Kumar Agrawal, S Singh, BA Bhat, AK Saxena, HMS Kumar and GN Qazi. Synthesis and biological evaluation of 4b-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents. Chemistry and Biodiversity, 5, 2008, 1792-1802.
  30. MPS Ishar, T Raj, Satyam Kumar Agrawal, AK Saxena, L Singh, R Singh and SS Bhella. Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones. Bioorganic & Medicinal Chemistry Letters18(17), 2008, 4809-4812.
  31. TS Thind, Satyam Kumar Agrawal, AK Saxena and S Arora. Studies on cytotoxic, hydroxyl radical scavenging and topoisomerase inhibitory activities of extracts of Tabernaemontana divaricata (L.) R.Br. ex Roem. and Schult. Food and Chemical Toxicology, 46(8), 2008, 2922-2927.
  32. PB Reddy, D Paul, Satyam Kumar Agrawal, AK Saxena, HMS Kumar and GN Qazi. Design, Synthesis, and Biological Testing of 4b-[(4-Substituted)-1,2,3-triazol-1-yl] podophyllotoxin Analogues as Antitumor Agents. Pharm. Chem. Life Sci., 341, 2008, 126 – 131.
  33. Bilal A. Bhat, P. B. Reddy, Satyam Kumar Agrawal, AK Saxena, HMS Kumar, GN Qazi. Studies on novel 4β-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents. European Journal of Medicinal Chemistry, 43, 2008, 2067-2072.

Books Edited

  1. Nanotechnology: Novel Prospectives and Prospects. Edited by: B Singh, A Kaushik, SK Mehta, SK Tripathi; Associate Editors: S Kapoor, Satyam K Agrawal. McGrawHill, ISBN No: 93-39221-09-5, 2015, Pages – 924.

Book Chapter

  1. Madhunika Agrawal and Satyam Kumar Agrawal, “Implications of NRF-2 in Cancer Progression and Therapeutics”. In: Chakraborti S. (eds.) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, by Springer, Singapore, ISBN No: 978-981-16-1247-3, 2022, pp 1-17; https://doi.org/10.1007/978-981-16-1247-3_79-1.
  2. Madhunika Agrawal and Satyam Kumar Agrawal. Emerging Field of Nanocarriers for Efficient Delivery of Chemopreventive Nutraceuticals. In Volume 3, NanoBioMedicine: NanoNutraceuticals, published by CRC Press, Taylor and Francis Group, FL, ISBN No: 97-80815-3999-26, 2018, pp 43-56; https://doi.org/10.1201/9781351138949-3.
  3. Ravinder Kaur, Rajneet Kaur, Kriti Singh, Atul Jain, Satyam Kumar Agrawal, Bhupinder Singh. Development, Optimization and Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) of Telmisartan. In Nanotechnology: Novel Prospectives and Prospects, by McGraw Hill, ISBN No: 93-39221-09-5, 2015, pp 703-709.

SPECIALISATION:

Biotechnology, Life Sciences

AREA OF RESEARCH/TEACHING INTEREST:

Cell & Molecular Biology, Nanotechnology, Anticancer Biology, Genomics, Research Methodology & Biostatistics.

Workshops Conducted/Organised

  1. As Resource Person for conducting One day workshop on Ethical Guidelines for Human Research”, at Chitkara School of Health Sciences, Chitkara University, Rajpura, on May 6, 2022.
  2. Organised a Three-day event on account of National Science Day celebrations, comprising of Science Talk, Science Quiz, Poster presentations and Declamation competitions, at Chitkara University, Rajpura , during March 10-12, 2022.
  3. Conducted a three day workshop entitled “Cell Culture – Skill course” at Department of Health Research – Multidisciplinary Research Unit, King Georg`s Medical University (KGMU), Lucknow, during Dec 03-05, 2018.
  4. Conducted a one day workshop on “Applications of Flow cytometry in Oncology” at “International Oral Pre-Cancer & Cancer Congress: Translational Oncology & Genomics” during Feb 11-13, 2016, at KG Medical University, Lucknow.
  5. As Resource Person during Training school, for Workshop on “Applications of Confocal Microscopy in Nanotechnology” at “From Drug Discovery to Drug Delivery: Contemporary Trends” from 16-21 March 2015, at Panjab University, Chandigarh.
  6. As Resource Person during Training school, for Workshop on “Applications of Confocal Microscope in Pharmaceutical Industry” at “Emerging Tools & Techniques in Pharma Res & Innovation” from 9-14 Feb 2015, at Panjab Univ., Chandigarh.
  7. Organised a workshop on “Applications of Confocal Microscopy & Photon Imager in Nanotechnology research” for delegates attending “4th Winter School on Nanotechnology in Advanced Drug Delivery”, held during Feb 28-March 04, 2011, at Centre for Pharmaceutical Nanotechnology, NIPER, Mohali.
  8. Organised a workshop on “Practical applications of Confocal Microscopy & Photon Imager in Nanotechnology” for delegates/students attending “3rd Summer School on Nanotechnology in Advanced Drug Delivery”, held during Aug 23-27, 2010, at Centre for Pharmaceutical Nanotechnology, NIPER, Mohali.
  9. Organised a workshop on “Confocal Microscopy & Photon Imager: Tools and Techniques” for delegates/students attending “3rd Winter School on Nanotechnology in Advanced Drug Delivery”, held during Feb 08-12, 2010, at Centre for Pharmaceutical Nanotechnology, NIPER, Mohali.
  1. In vitro cytotoxicity assays on human cancer cell lines.
  2. Anticancer mechanism of action of new plant isolates and synthetic molecules.
  3. Activity guided isolation of natural products.
  4. Project planning of Western Blot, Microscopy and other Molecular Biology studies.
  1. Qualified CSIR-UGC-JRFship & NET June 2004
  2. Qualified CSIR-UGC-NET-LS Dec 2003
  3. Qualified GATE 2005, Percentile Score- 84.73
  4. Dept. of Biotechnology, GoI, Scholarship during M.Sc. Biotechnology (2002-2004)
  5. 1st place at the CSIR Foundation Day Science Quiz, at IIIM-2006; 2nd at IIIM -2005
  6. International Travel Grant from CCR, NCI for attending TAT 2009, Amsterdam (2009)
  7. First place at the NIPER Foundation Day Science Quiz-2011 & 2012
  8. Certified trainer form LSSSDC, New Delhi for several courses in 2021

Life member-

  • Indian Association of Cancer Research (IACR)
  • The Society of Biological Chemists (India) (SBC(I))
  • The Biotech Research Society, India (BRSI)
  • Indian Society for the Study of Reproduction and Fertility (ISSRF)
  • The Bioelectromagnetics Society of India (BESI)
  • Society of Toxicology (STOX), India
  1. Automated System for Analyzing Morris Water Maze Test. V Khullar, Satyam Kumar Agrawal and Madhunika Agrawal. Patent application no. 202211010383; 11235/2022-DEL. Filed date: 26/02/2022.
  2. Morris Water Maze Tank with Intelligent Monitoring. Satyam Kumar Agrawal, V Khullar and Madhunika Agrawal. Design Patent application No. 361484-001. Filed date: 29/03/2022.
  3. Novel-4-beta-[(4-substituted)-1,2,3-Triazol-1-yl]Podophyllotoxins as Potential Anticancer Agents. GN Qazi, HMS Kumar, AK Saxena, PB Reddy, BA Bhat and Satyam Kumar Agrawal. Application no: 528/DEL/2008, Patent no. 285048, Granted on: 11/07/2017.
  4. Semi-Synthetic Sesquiterpene Lactone Parthenin Compound Useful for Cytotoxicity Against Cancer Cell Lines and Anticancer Agent. GN Qazi, SC Taneja, J Singh, AK Saxena, VK Sethi, BA Shah, A Kumar, SS Andotra, F Malik, S Muthiah and Satyam Kumar Agrawal. WOPatent Publication No.: WO 2009/122447 A1; PCT/IN2009/00218.
  5. Novel Efflux Pump Inhibitors. S Koul, N Thota, MV Reddy, PL Sangwan, SC Taneja, IA Khan, A Kumar, RA Fida, AK Saxena, Satyam Kumar Agrawal, RK Johri, ST Abdullah, G Singh, BLN Rao, AK Dhar, B Purnima and GN Qazi. WO Patent Publication No.: WO2009/110002 A4; PCT/IN2009/000144.
  6. Novel Substituted 2,2,6-trimethyl-7,9,10-trioxa-tricyclo[6.2.2.0.1,6]dodec-11-enes(Endoperoxides). MPS Ishar, L Singh, R Singh, AK Saxena, DM Mondhe, Satyam Kumar Agrawal and HC Pal. Patent Filed: 1755/DEL/2010.
  7. Novel-4-beta-[(4-substituted)-1,2,3-Triazol-1-yl]Podophyllotoxins as Potential Anticancer Agents. GN Qazi, HMS Kumar, AK Saxena, PB Reddy, BA Bhat and Satyam Kumar Agrawal. Patent Filed: 0528/DEL/2008.
  • Ph.D. (Life Sciences; Anticancer Biology), Guru Nanak Dev University, Amritsar
  • M.Sc. (Biotechnology), University of Allahabad, Allahabad
  • B.Sc., VBS Purvanchal University, Jaunpur

More than 17 years in Research (2005 to date):

Current Position:

  • Professor (Research) at Chitkara University Research and Innovation Network (CURIN), Chitkara University, Punjab from Dec 2021 onwards.

Previous Positions:

  • Professor at School of Pharmacy, Baddi University, HP, Nov 2019 – Dec 2021.
  • Scientist C at Div. of Rep. Biology, Maternal & Child Health, Indian Council of Medical Research (ICMR), Head-Quarters, New Delhi, Sept 2017 – Oct 2019.
  • Project Scientist at CSIR-Institute of Genomics and Integrative Biology, New Delhi, from Jul 2015- March 2017.
  • On several project based Scientific and Research positions at NIPER, CDRI & PU and in Industry from Jan 2010 – June 2015.
  • CSIR-JRF, SRF at CSIR-Indian Institute of Integrative Medicine, Jammu from Jan 2005 – Jan 2010.