Synergsitic Composition for The Treatement of Neurological Disorders

The present invention discloses a synergistic composition of two therapeutic compounds – Scopolamine (for treatment of nausea, vomiting and post-operative sickness) and drug Venlafaxine (for the treatment of depression) in specific optimal ratio of 100:1 which is beneficial for treatment of drug resistant depression, without undesirable effects. Scopolamine thus acts as a potency enhancing agent for enhancing the potency of existing anti-depressant drugs without adverse effects. Behavioral studies in mice indicated that combination of Scopolamine and Venlafaxine showed synergistic hyper-additive antidepressant effect, which significantly (P < 0.0001) decreased the immobility time and had no detrimental effect on memory thus providing a potent therapeutic combination for treatment of drug resistant depression.

Inventors

Mohd Arshad, Paramdeep Singh, Thakur Gurjeet Singh

Patent File Number - 2190/DEL/2015        Patent File Date - 20/07/2015