Synergistic Composition of Scopolamine And Venlafaxine for Treatment of Drug Resistant Depression

The present invention discloses a synergistic composition of two therapeutic compounds – Scopolamine (for treatment of nausea, vomiting and post-operative sickness) and drug Venlafaxine (for the treatment of depression) in specific optimal ratio of 100:1 which is beneficial for treatment of drug resistant depression, without undesirable effects. Scopolamine thus acts as a potency enhancing agent for enhancing the potency of existing anti-depressant drugs without adverse effects. Behavioral studies in mice indicated that combination of Scopolamine and Venlafaxine showed synergistic hyper-additive antidepressant effect, which significantly (P < 0.0001) decreased the immobility time and had no detrimental effect on memory thus providing a potent therapeutic combination for treatment of drug resistant depression.


Thakur Gurjeet Singh, Paramdeep Singh

Patent File Number - 3102/DEL/2015        Patent File Date - 29/09/2015