Solid Dispersion formulation of Lamotrigine

The present disclosure relates generally to the field of Pharmaceuticals. Particularly, the present disclosure provides solid dispersion formulation of Lamotrigine. Aspects of the present disclosure also relates to a method of preparation of solid dispersion formulation of Lamotrigine. The present disclosure is on a premise that a solid dispersion formulation of Lamotrigine, said formulation comprising Lamotrigine and modified locust bean gum (MLBG) in a weight ratio ranging from 1:1 to 1:7 surprisingly improves the equilibrium solubility of Lamotrigine by about 2.5 times as compared to that of the Lamotrigine. Accordingly, an aspect of the present disclosure provides a solid dispersion formulation of Lamotrigine, said formulation comprising Lamotrigine and modified locust bean gum in a weight ratio ranging from 1:1 to 1:7.

Inventors

Manju Nagpal, Riya, Thakur Gurjeet Singh, Geeta

Patent File Number - 201911004379        Patent File Date - 04/02/2019