The present disclosure relates generally to the field of Pharmaceuticals. Particularly, the present disclosure provides solid dispersion formulation of Lamotrigine. Aspects of the present disclosure also relates to a method of preparation of solid dispersion formulation of Lamotrigine. The present disclosure is on a premise that a solid dispersion formulation of Lamotrigine, said formulation comprising Lamotrigine and modified locust bean gum (MLBG) in a weight ratio ranging from 1:1 to 1:7 surprisingly improves the equilibrium solubility of Lamotrigine by about 2.5 times as compared to that of the Lamotrigine. Accordingly, an aspect of the present disclosure provides a solid dispersion formulation of Lamotrigine, said formulation comprising Lamotrigine and modified locust bean gum in a weight ratio ranging from 1:1 to 1:7.
Inventors
Manju Nagpal, Riya, Thakur Gurjeet Singh, Geeta
