The present disclosure provides a pharmaceutical composition comprising of N-benzyloxycarbonyl-leucyl-leucyl-phenylalanal (Z-Leu-Leu-Phe-CHO), a selectiveinhibitor of ubiquitin proteasome system, which is found to have dose-dependentand marked attenuation of the seizure development including one or more10 conditions selected from the group consisting of acute seizure, repetitive seizures,and status epilepticus-induced spontaneous recurrent seizures. The presentdisclosure also provides a methods for producing injectable formulationscompositions comprising of Z-Leu-Leu-Phe-CHO, pharmaceutically acceptableexcipients and the like.
Inventors
Thakur Gurjeet Singh, Shareen Singh, Sonia Dhiman
