PHARMACEUTICAL COMPOSITION COMPRISING UBIQUITIN–PROTEASOME SYSTEM INHIBITOR FOR ATTENUATING SEIZURE DEVELOPMENT

The present disclosure provides a pharmaceutical composition comprising of N-benzyloxycarbonyl-leucyl-leucyl-phenylalanal (Z-Leu-Leu-Phe-CHO), a selective inhibitor of ubiquitin proteasome system, which is found to have dose-dependent and marked attenuation of the seizure development including one or more 10 conditions selected from the group consisting of acute seizure, repetitive seizures, and status epilepticus-induced spontaneous recurrent seizures. The present disclosure also provides a methods for producing injectable formulations compositions comprising of Z-Leu-Leu-Phe-CHO, pharmaceutically acceptable excipients and the like.

Inventors

THAKUR GURJEET SINGH, SHAREEN SINGH, SONIA DHIMAN

Patent File Number - 202111004317         Patent File Date - 01/02/2021