The present invention discloses novel compounds which are derivatives of ferulic acid, for use as anti-inflammatory agents. The derivatives are prepared using Mannich reaction. In Mannich reaction, formaldehyde or paraformaldehyde is condensed with
ammonia in the form of its salt and a compound containing active hydrogen. This may formally be considered as an addition of ammonia to give H2N-CH2-OH, followed by a nucleophilic substitution. Instead of ammonia, the reaction is carried out with salts of primary or secondary amines or with amides, in which cases the product is substituted on the nitrogen with R, R2 and RCO respectively.
Sandeep Arora, Mansi Chitkara, Ritchu Babbar, I S Sandhu, S C Sharma