The present invention discloses modified coarse grain starch from natural sources, for pharmaceutical use. Starch from millet, sorghum and cocoyam was modified by thermal treatment (pre-gelatinization) and showed following characteristics viz. particle size between 50-300 micrometres; absence of crystalline peaks in XRD spectra; bulk density between 0.5 to 0.7 g/cm3; tapped density between 0.6 to 0.8 g/cm3; Carrs index (%) between 14 to 20%; Hausners ratio between 1 to 1.20 and swelling ratio (%) between 4 to 6. The modified starch provided a better drug dissolution profile when compared to the native form of the same starch. The method of preparing the modified starch was simple involving preparing a 20% w/v aqueous slurry and heating at 100 degree Celsius for 45 minutes, followed by drying and sieving using 60 mesh sieve to obtain final product.
INDERBIR SINGH, ODEKU ADEPEJU OLUWATOYIN, ALABHI OLUWAPONMILE CECILIA