Dr. Mohit Kapoor
Assistant Professor

mohit.kapoor@chitkara.edu.in

Expert Areas : Late-Stage C-H functionalization, Antiviral Leads, Cancer Diagnostics, Sustainable Chemistry

Dr Mohit Kapoor is PhD in Medicinal and Sustainable Organic Chemistry with 6 years of experience in Research, Development, Training, and Academics. His areas of expertise are Medicinal chemistry, Bio-organic Chemistry, Catalysis, Organometallic chemistry, Nanomaterial, and Sustainable Organic Chemistry.

He has spent quality of his time doing research in Taiwan and the USA. After PhD and brief Postdoc under the guidance of Prof. Reuben Jih-Ru Hwu at National Tsing Hua University, Taiwan he moved to The University of Toledo, Ohio, USA as a Postdoctoral Research Scholar with Prof. Michael Young.

He has published many high-tier and internationally reputed journals in the field of catalysis, medicinal chemistry, and nanotechnology. Now, he is establishing his state-of-art research lab at CURIN, Chitkara. He has several international collaborations in Taiwan, and the USA. When not in the lab, Mohit enjoys riding and taking hikes with his wife. His area of interests includes:

1. Investigation of Endogenous Gaseous Transmitters Role in Cancer Chemotherapy.
2. Development of New Carbon Based Diagnostic Tools for MRI.
3. Designing Novel Methodologies for the Late-Stage Functionalization of Complex Molecules.

  • Research
  • Teaching
  • Awards
  • Patents
  • Education
  • Service

PUBLICATIONS:

  1. Kapoor, M.;* Singh, A.; Sharma, K.; Hsu, M. H. Site-Selective C(sp3)‒ and C(sp2)‒H Functionalization of Amines Using A Directing Group Guided Strategy. Adv. Synth. Catal. 2020, https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202000689. Impact Factor: 5.81. (Selected as HOT ARTICLE IN C-H ACTIVATION AND SUSTAINABLE CHEMISTRY)
  2. Chand-Thakuri, P.; Landge, V. G.; Kapoor, M.; Young, M. One Pot C‒H Arylation/Lactamization Cascade Reaction of Free Benzylamines. J. Org. Chem. 2020https://doi.org/10.1021/acs.joc.0c00542. Impact Factor: 4.9.
  3. Hsu, M.-H.; Hsieh, C.-Y.; Kapoor, M.; Chang, J.-H.; Chu, H.-L.; Cheng, T.-M.; Hsu, K.-C.; Lin, T. E.; Tsai, F.-Y.; Horng, J.-C. Leucettamine B Analogs and their Carborane Derivative as Potential Anti-Cancer Agents: Design, Synthesis, and Biological Evaluation. Bioorg. Chem. 2020, https://doi.org/10.1016/j.bioorg.2020.103729. Impact Factor: 3.99
  4. Singh, A.; Hsu, M. H.; Khanra, P.; Kumar, P.; Gupta, N.; Verma, V. P.; Kapoor, M. Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells. ChemPlusChem, 2020, 85, 466-475. Impact Factor: 3.441
  5. Landge, V. G.; Maxwell, J. M.; Chand-Thakuri, P.; Kapoor, M.; Evan Diemler, E.; Young, M. γ-C (sp2)–H Arylation of Allylamines Using PdII and CO2 as a Transient Directing Group. ChemRxiv, 2020.
  6. Hsieh, C.-Y.; Ko, P.-W.; Chang, Y.-J.; Kapoor, M.; Liang, Y.-C.; Lin, H.-H.; Horng, J.-C.; Hsu, M.-H. Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents. Molecules 201924, 3259. Impact Factor:  3.016
  7. Kapoor, M.; Chand-Thakuri, P.; Young, M. C. Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines. J. Am. Chem. Soc. 2019, DOI: 10.1021/jacs.9b03375. ISSN: 0002- 7863, 1520-5126. Impact Factor: 14.697
  8. Kapoor, M.; Liu, D.; Young, M. C. Carbon Dioxide Mediated C(sp3)–H Arylation of Amine Substrates. J. Am. Chem. Soc. 2018, 140, 6818–6822 (Most Read Article in Journal of American Chemical Society, Research covered in ten newspapers). ISSN: 0002- 7863, 1520-5126. Impact Factor: 14.697
  9. Kapoor, M.; Chand-Thakuri, P.; Maxwell, J. M.; Liu, D.; Zhou, H.; Young, M. C. Carbon Dioxide-Driven Palladium-Catalyzed C–H Activation of Amines: A Unified Approach for the Arylation of Aliphatic and Aromatic Primary and Secondary Amines. Synlett (Synpacts), 2018.Impact Factor: 2.369.
  10. Kapoor, M.; Chand-Thakuri, P.; Young, M. C. Carbon Dioxide Facilitated C(sp2)–H Arylation of Primary and Secondary Benzylamines. ChemRxiv. Preprint. 2018,https://doi.org/10.26434/chemrxiv.7138088.v1.
  11. Kapoor, M.; Chand-Thakuri, P.; Maxwell, J. M.; Young, M. C. Achieving Moderate Pressures in Sealed Vessels Using Dry Ice as a Solid CO2 Source. J. Vis. Exp. 2018, 138, e58281, doi:10.3791/58281. ISSN: 1940-087X. Impact Factor: 1.325
  12. Kapoor, M.; Hwu, J. R.*Na@SiO2-Mediated Addition of Organohalides to Carbonyl Compounds for the Formation of Alcohols and Epoxides. Nature Scientific Rep.2016, 6, 36225. ISSN: 2045-2322. Impact Factor: 4.259
  13. Hwu, J. R.*; Kapoor, M.; Tsay, S. C.*; Lin, C. C.; Hwang, K. C.; Horng, J. C.; Chen, I. C.; Shieh, F. K.; Leyssen, P.; Neyts, J*. Benzouracil–Coumarin–Arene Conjugates as Inhibiting Agents for Chikungunya Virus.Antiviral Res. 2015, 118, 103–109. ISSN: 0166-3542. Impact Factor: 4.909
  14. Hwu, J. R.*; Kapoor, M.; Li, R. Y.; Lin, Y. C.; Horng, J. C. *; Tsay, S. C*. Synthesis of Nucleobase-Functionalized Carbon Nanotubes and Their Hybridization with Single-Stranded DNA.Chem. Asian J.2014, 9, 3408–3412 (Cover Page Article). ISSN: 1861-471X. Impact Factor: 4.083
  15. Chuang, H.; Huang, L. C. S.; Kapoor, M.; Liao, Y. J.; Yang, C. L.; Tu, L. C.; Chang, C. C.; Hwu, J. R.*; Huang, T. J.*; Hsu, M. H*. Design and Synthesis of Pyridine-Pyrazole-Sulfonate Derivatives as Potential Anti-HBV Agents.Med. Chem. Commun. 2016, 7, 832–836. ISSN: 2040-2511. Impact Factor: 2.495
  16. Tsai, C.-Y.; Kapoor, M.; Huang, Y.-P.; Lin, H.-H.; Liang, Y.-C.; Lin, Y.-L.; Huang, S.-C.; Liao, W.-N.; Chen, J.-K.*; Huang, J.-S.; Hsu, M.-H.* Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents. Molecules 2016, 21, 145; doi:10.3390/molecules21020145. ISSN: 1420-3049. Impact Factor: 2.861.
  17. Hwu, J. R.*;Tsay, S. C.*;Chuang, K. S.; Kapoor, M.; Lin, J. Y.; Yeh, C. S.;Su, W. C.; Wu, P. C.; Tsai, T. L.; Wang, P.-W.; Shieh, D. B*. Syntheses of Platinum–Sulindac Complexes and Their Nanoparticles as Targeted Anti-cancer Drugs.Chem. Eur. J. 2016, 22, 1926–1930. ISSN: 1521-3765. Impact Factor: 5.317.
  18. Huang, L. C. S.; Chuang, H.; Kapoor, M.; Hsieh, C. Y.; Chou, S. C.; Lin, H. H.; Chen, Y. W.; Hwu, J. R.*; Liang, Y. C.*; Hsu, M. H*. Development of Nor-dihydroguaiaretic Acid Derivatives as Potential Multidrug-Resistant Selective Agents for Cancer Treatment.RSC Adv. 2015, 5, 107833–107838. ISSN: 2046- 2069. Impact Factor: 3.108

 

PUBLICATIONS UNDER PROCESS:

  1. Hwu, J. R.; Patil, U.; Kapoor, M.; Horng, J.-C.; Lin, C.-C.; Tsay. S.-C. Entwinement of Grafted Nanotubes by DNA as Biochemical Rod of Asclepius. Submitted.
  2. Hwu, J. R.*;Tsay, S. C.*;Chuang, K. S.; Kapoor, M.; Lu, K.-L. L.; Lin, J. Y.; Lin, C.-C.; Josephrajan, T.;Huang, K. P.; Yeh, C. S.;Su, W. C.; Wu, P. C.; Tsai, T. L.;Shieh, D. B*. Dual Biomedical Functions of Sulfoxide–Platinum Complexes and Their Encapsulation in Nanoparticles.In Preparation

 

INTERNATIONAL CONFERENCES:

  1. Mohit Kapoor (Invited Lecture) Transient Carbamate Guided C-H Activation for the Functionalization of Amines. 18th Asian Chemical Congress, Taipei, Taiwan, December 8-12, 2019
  2. M Young, M Kapoor, P Chand-Thakuri, J Maxwell. Adventures in CH activation with carbon dioxide. American Chemical Society Conference (ACS), Orlando, USA, March 31, 2019. Fear is more LETHAL than VIRUS
  3. Mohit Kapoor. Carbon dioxide mediated C-H activation for the functionalization of amines: A traceless directing group strategy. American Chemical Society Conference (ACS), Boston, USA, August 23, 2018.
  4. Mohit Kapoor. (Invited Lecture) Carbon Dioxide Mediated Functionalization of Aliphatic and Aromatic Amines: A Green Pathway for Functionalized Amines. American Chemical Society Conference (ACS), Toledo, Ohio, USA, June 15, 2018
  5. Mohit Kapoor. Carbon Dioxide Mediated C-H Activation: A Traceless Directing Group Strategy for the Functionalization of Amines. 35th Annual H.C. Brown Lectures, Purdue University, Indiana, USA, April 12-13, 2018
  6. Jih Ru Hwu, Mohit Kapoor and Shwu-Chen Tsay. Advanced New Drug Development and Their Delivery by Nanomaterials. Presentation to be deliverd at the“1st International Conference on Applied Chemistry”, Sohag University, Egypt, March 14-17, 2016.
  7. Jih Ru Hwu, Mohit Kapoor, Shwu-Chen Tsay, and UttamPatil. Synthesis of Nucleobase-Functionalized Carbon Nanotubes and Their Hybridization with Single-Stranded DNA. Presentation and poster delivered at the 5th International Conference on Cutting-edge Organic Chemistry in Asia” (ICCEOCA-5), Tainan, Taiwan, Oct. 2-Nov.5, 2015.
  8. Animesh Roy, Mohit Kapoor, Shwu-Chen Tsay, and Jih Ru Hwu. Design and Synthesis of Benzouracil Coumarin Sulfonate Conjugates as Chikungunya Virus Inhibitor. Poster presented at the 5th Junior International Conference on Cutting-edge Organic Chemistry in Asia” (JICCEOCA-5), Taipei, Taiwan, Oct. 30-Nov.1, 2015.
  9. Jih Ru Hwu, Shwu Chen Tsay, Mohit Kapoor, Pieter Leyssen,and Johan Neyts. New Anti-Infective Agents For Emerging Diseases.Poster prsented at the 10th AFMC International Medicinal Chemistry Symposium (AIMECS 2015), Korea, Oct. 18-21.
    Jih Ru Hwu, Mohit Kapoor, Shwu Chen Tsay. Modern Developments in New Drugs and Their Delivery by Nanomaterials. Presentation delivered at the MedChem, Russia, July 5-10, 2015.
  10. Jih Ru Hwu, Mohit Kapoor, Yung-Chieh Lin, Yu Sern Lin, Rou Ying Li, and Shwu-Chen Tsay. Novel Functional Nano-materials for Drug Delivery. Presentation delivered at the International Conference on Advanced Materials and Nanotechnology for Sustainable Development, Nepal, Nov. 4-6, 2014.
  11. Jih Ru Hwu, Mohit Kapoor, Yung-Chieh, Lin,Yu Sern Lin, Rou-Ying Li,Jia-CherngHorng,and Shwu-Chen Tsay. Nanoparticles and Nanotubes as Vehicles for Bioactive Compounds. Presentation delivered at the International Symposium of Organic Chemistry (ISOR), Taipei, Taiwan, Nov. 19-22, 2013.
  12. Shwu-Chen Tsay, Mohit Kapoor, John Neyts, Pieter Leyssen, Jih Ru Hwu. Design and Synthesis of Novel Pyrimidine–Coumarin Conjugates as Anti-Chikungunya Agents. Presentation delivered at the Chikungunya 2013, Malaysia, Oct. 28-30, 2013.
  13. Mohit Kapoor, Shwu-Chen Tsay,Shu-Yu Lin,John Neyts,andJih Ru Hwu. Development of Coumarin–Purine and –Pyrimidine Conjugates asNew Leads Against RNA Viruses.Poster presented at the 13th Tetrahedron Symposium, Taipei, Taiwan, Nov. 27-30, 2012.
  14. Mohit Kapoor, Shwu-Chen Tsay,Shu-Yu Lin,John Neyts,andJih Ru Hwu. Syntheses of Coumarin–Purine and –Pyrimidine Conjugates as New Agents against Hepatitis C Virus. Presentation and poster delivered at the Advanced Version of WOCJC, Tokyo Institute of Technology, Tokyo and International Symposium of Organic Chemistry (ISOR), Yokohama, Japan, Nov. 21-23, 2011.

 

BOOK CHAPTER:

  1. Hwu, J. R.*; Pradhan, T. K.; Tsay, S. C.;Kapoor, M.; Bachurin, S. O.; Raevsky, O. A.; Neyts, J. Antiviral Agents towards Chikungunya Virus: Structures, Syntheses, and Isolation from Natural Sources. Springer: New Horizons of Process Chemistry 2017, pp 251–274
PROCEEDINGS:
  1. Sharma, K.; Patil, U. Y; Kapoor, M*. Study the alkylation behavior of 1,3-dicarbonyl systems with alkyl halides. AIP Proceedings, 2020.
  2. Singh, A.; Patil, U. Y. Khanra, P.; Kumar, P.; Kapoor, M*. Structural and stability profile of suramin-bound single-walled carbon nanotubes. AIP Proceedings, 2020.
  3. Khanra, P.; Kapoor, M.; Kumar, P. Facile Synthesis of Graphene/Manganese Carbonate as Cathode Materials for Supercapacitor Application. AIP Proceedings, 2020.
  4. Gupta, N.; Sen, K.; Singh, V.; Soni, A.; Kapoor, M.; Electrochemical Sensing of Dopamine using Graphene Oxide Derived from Pine Needle Bio-waste. AIP Proceedings, 2020.

• Spectroscopy
• Drug design and Development
• Organic Chemistry & Advanced Organic Chemistry
• Organometallic Chemistry
• Medicinal Chemistry
• Nanotechnology
• Colloids & Nanoparticles
• Heterogeneous Catalysis
• Green Chemistry

Collaborators:
1. Prof. Kulmira Nurgali MBBS, MSc, PhD
Western Centre for Health, Research & Education, Sunshine Hospital
College of Health and Biomedicine, Victoria University
Department of Medicine, Western Health, Melbourne University, Australia
Ph.: 03 83958223; 0457 212 886
E-mail: Kulmira.Nurgali@vu.edu.au

2. Prof. Sanjiv Kumar
Department of Oncology and Pathology
Karolinksa Institutet, Stockholm, Sweden

3. Prof. John Moma
School of Chemistry,
Room C508, Humphrey Raikes Building,
University of the Witwatersrand, Johannesburg,
1 Jan Smuts Avenue, Braamfontein 2001,
Private Bag X3, PO WITS 2050, South Africa

4. Prof. Zhong-Shuai Wu
Dalian National Laboratory For Clean Energy
Dalian Institute of Chemical Physics
Chinese Academy of Sciences
457 Zhongshan Road, Dalian 116023, China

5. Prof. Ming Hua Hsu
Department of Chemistry
National Changhua University of Education
Changhua, Taiwan 500, R.O.C.
Tel: +886-3-573-1180; Fax: +886-3-572-5974

1 Invited talk at 18th Asian Chemical Congress held in Taiwan during Dec 08th to Dec 12th, 2019 on the topic of Sustainable Chemistry.
2 Biotechnology Industry Research Assistance Council (BIRAC) Appreciation Award in Evolution of Smart MRI Contrast Agents: A New Generation of Imaging
3 Invited Lecture at American Chemical Society (ACS), Ohio, USA on 06/2018. Title: Carbon Dioxide Mediated Functionalization of Aliphatic and Aromatic Amines: A Green Pathway for Functionalized Amines.
4 Postdoctoral Fellowship, Ministry of Science and Technology, Taiwan from 2015−2016.
5 National Tsing Hua University International fellowship for PhD, 2011−2013.

  • Mohit Kapoor, Partha Khanra, Pankaj Kumar. Gene Targeted Metal Decorated Nanomaterial’s as Novel MRI Agents. Indian Patent 2019, 201911020198.
  • Mohit Kapoor, Adhish Singh, Neha Sardana. AN AIR FILTRATION APPARATUS FOR FILTERING MICRO-ORGANISMS. Indian Patent, 2020, 202011029313.
  • Kapoor, M.; Young, M. C. Carbon dioxide as a directing group for C-H functionalization reactions. US Patent Application, 2018,16/223,467.
  • Kapoor, M.; Hsu, M.-H.; Chen, J.-K. Novel N-Heterocyclic Scaffolds as Antineoplastic Agents. Indian Patent, 2019, 201911013055.

PhD (Medicinal & Organic Chemistry, Nanotechnology), National Tsing Hua University, Hsinchu, Taiwan 09/2010−11/2014.
Thesis: Design and development of small molecules against emerging and neglected viruses in collaboration with SILVER FP7, Belgium and novel method of C−C bond formation in organic syntheses.
Masters of Science (Pharmaceutical Chemistry)2006−2008 & Bachelor of Science (Organic Chemistry) 2003−2006 from Kurukshetra University, Haryana, India.

  • Visiting Researcher, National Changhua University of Education Changhua, Taiwan – 12/2019
  • Postdoctoral Research Scholar (Catalysis, Organometallic Chemistry) at The University of Toledo, Ohio, 04/2017–12/2018
  • Postdoctoral Fellow (Nanotechnology, Medicinal and Organic Chemistry) at National Tsing Hua University, Hsinchu, Taiwan 03/2015−10/2016
  • Jubilant Life Sciences Ltd. Noida, India Research Associate 10/2008−08/2010