The present invention relates to pharmaceuticals. Specifically, the present invention relates tonovel glucokinase activator compounds of Formula I, their pharmaceutically acceptabletautomers, isomers and salts thereof, exhibiting therapeutic activity and acting as anti-diabeticagents. The present invention further relates to process for preparation of compounds of FormulaI. The present invention also relates to In silico evaluation of the compounds of Formula I using10 AutoDock Vina and AutoDock Tools. The present invention relates to compounds of Formula Iacting as allosteric activators of human glucokinase.
Sukhbir Singh, Ervon Dhalio, Kunal Arora, Ajmer Singh Grewal, Neelam Sharma, Sandeep Arora